Nanotechnology World Conference 2026

Abstract

This study aims to evaluate, histologically, the regenerative potential of novel injectable boron doped mesoporous bioactive glass nanoparticle BMBGNPs loaded alginate hydrogel. Methods  Formulation and optimization of the novel alginate/BMBG NPs 20 wt.% loaded composite hydrogel were performed. Next, sixty six teeth of three dogs were allocated into three groups each including 22 teeth according to post  operative follow up period group I 2 weeks, group II 4 weeks, group III 8 weeks. Each group was further subdivided according to pulpotomy filling material into two subgroups, with subgroup 1 alginate/BMBGNPs 20 wt. % loaded hydrogel) and subgroup 2 MTA. Complete pulpotomy was executed. One dog was sacrificed after 2, 4 and 8 weeks. Teeth were prepared for histological evaluation assessing: inflammatory cell response, pulp tissue organization, dentin bridge formation. Mann Whitney U test was employed to evaluate the scores of histological parameters between tested materials (p 0.05).
Results Alginate/BMBG NPs  20 wt. loaded hydrogel showed normal pulp configuration at 2 and 4weeks which was enhanced after 8 weeks (p  0.05). Moderate inflammatory reaction was noted at 2 weeks which was improved after 4 and 8weeks (p  0.05). MTA group demonstrated less favorable pulpal response and inflammatory reaction with statistical significant difference across all observational periods (p ≤0.05). After 8 weeks all teeth in group 1exhibited thickest dentin bridge (p 0.05). Conclusions  Alginate BMBG NPs (20 wt. %) loaded hydrogel favors the promise to regenerate dentin and maintai