Paulo C. DE MORAIS (H 62), PhD, was full Professor of Physics at the University of Brasilia (UnB) Brazil up to 2013, Appointed as UnBs Emeritus Professor (2014), Appointed as Guest Professor of Huazhong University of Science and Technology China (2011), Visiting Professor at Huazhong University of Science and Technology (HUST) China (2012-2015), Appointed as Distinguished Professor at Anhui University (AHU) China (2016 to 2019), Appointed as Full Professor at Catholic University of Brasília (UCB) Brazil (2018), Appointed as CNPq 1A Research Fellowship since 2010. 2007 Master Research Prize from UnB, 2008 member of the European ERA NET Nanoscience Committee, Member of the IEEE Magnetic Society Technical Committee, Senior Member of the IEEE Society, 2012 Chinas 1000 Foreign Expert Recipient, and 2012 Academic Excellence Award from Brazilian Professors Union. He held two years (1987 to 1988) post-doc position with Bell Communications Research New Jersey, USA and received his Doctoral degree in Solid State Physics (1986) from the Federal University of Minas Gerais Brazil. He graduated in both Chemistry (1976) and Physics (1977) at UnB. Professor Morais is member of the Brazilian Physical Society and the Institute of Electrical and Electronics Engineers IEEE. He has served as referee for more than 50 technical journals, takes part of the Editorial Board of more than 15 technical journals and has conducted research on nanomaterials for over 40 years. He is known for his research in preparation, characterization and applications of nanosized materials (magnetic fluid, magnetoliposome, magnetic nanoemulsion, magnetic nanocapsule, magnetic nanofilm, magnetic nanocomposite, nanosized semiconductors, polymeric dots, carbon dots, and graphene quantum dots). With more than 500 published papers in peer reviewed journals, more than 14,500 citations, about 300 international invited talks (35 countries), and 16 filed patents. He has appeared in recent World ranking of top scientists, such as 2020 Stanford, 2022 Research.com, 2023 AD Scientific Index, 2023 Research.com, 2024 Elsevier, ONE Research Community, 2025 AD Scientific Index, 2025 Research.com, and 2025 Stanford Elsevier.
In this keynote talk, the Hill model will be explored to assess the Benchmark dose (BMD), the lethal dose 50 (LD50), the cooperativity (E) and the dissociation constant (K) while analyzing cell viability data using nanomaterials. The presentation is addressed to discuss the antitumor potential while combining radiofrequency (RF) therapy and selected nanomaterials. In particular, it will be discussed the use of nanocomposites, for instance graphene oxide (GO) surface functionalized with polyethyleneimine (PEI) and decorated with gold nanoparticles (GO PEI Au). Data collected from the cell viability assays using different tumor cell lines (e.g. LLC WRC 256 and B16 F10) will be presented and discussed. The findings will demonstrate that while the tested nanocomposite (e.g. GO PEI Au) may be biocompatible against different cancer cell lines in the absence of radiofrequency (nRF), the application of radiofrequency (RF) enhances the cell toxicity by orders of magnitude, pointing to prospective studies with the tested cell lines using tumor animal models.